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When drug-related allergens enter the skin, they react with drug-specific IgEeffector cell complexes and cause the release of histamine and other inflammatory mediators, which results in macroscopic skin symptoms and indicates the possibility of allergy (133)

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In subchondral bone, chronic mechanical stress leads to microfracture, osteosclerosis, and angiogenesis, often accompanied by excessive iron deposition and oxidative stress

The adsorption isotherm can provide the mode of interaction of inhibitors at the composite surface