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The latter is considered to be the rate-controlling enzyme for the catabolic conversion of hepatic cholesterol to bile acids for subsequent elimination in the feces

It is about 4.5 times more common among boys (1 in 42) than among girls (1 in 189)

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Nat Commun 11(1):3427 Zhang H, Lin C, Zeng C, Wang Z, Wang H, Lu J, Liu X, Shao Y, Zhao C, Pan J, Xu S, Zhang Y, Xie D, Cai D, Bai X (2018) Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2

[DOI] [PubMed] [Google Scholar] 35.Kern J.K., Geier D.A., Adams J.B., Garver C.R., Audhya T., Geier M.R