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H 2 O 2 has a longer half-life and can cross membranes (Cadenas and Davies, 2000), consequently it has been identified as a suitable second messenger molecule, in part because of its reactions with specific oxidation-prone protein cysteinyl residues (Sies, 2014), which confers properties to H 2 O 2 as a mitochondrial signal (Raimundo, 2014)

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