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Variances in circadian phase, light responsiveness, and clock gene expression identified between older and younger adults [41], could lead to a different reaction to vitamin B12

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AOD-9604s lack of IGF-1 impact may make it more appropriate for individuals with these concerns, though individual medical evaluation remains essential

The best cutoff value for diagnosing vitamin B12 deficiency and the usefulness of vitamin B12 biomarkers, particularly in asymptomatic patients, remain controversial

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