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The linker must be stable enough to avoid premature release and sensitive enough to ensure efficient release upon cellular uptake

2000Physiological Reviews

10.1074/jbc.275.18.13727 157 Petaja-RepoU

If the results are low, or even at the low end of the normal range, cobalamin supplementation is called for

Supporting the previously demonstrated role of glucose metabolism in Bb infection (13), lactate was among the most significantly affected metabolites

Initially, the pathogenesis of NASH was explained by the 2-hit hypothesis, where the first hit, hepatic triglyceride accumulation (steatosis), increases the livers susceptibility to injury from second hits, such as inflammatory cytokines, mitochondrial dysfunction, and oxidative stress [37,38]