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The second trial, conducted at Peking University Third Hospital (Ethical code: D2020188), was a Phase I clinical triala randomized, double-blind, controlled study aimed at assessing the safety and preliminary efficacy of DPSC therapy at varying dose concentrations, carried out from July 31, 2021, to December 24, 2022

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Specifically, albuminuria was associated with deficits in attention and executive function, while low eGFR was linked to a decrease in psychomotor speed (119)

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The mechanisms involved in the proper functioning of the IEB include the transport of molecules across the intestinal mucosa through two distinct mechanisms: paracellular diffusion through TJs between adjacent intestinal epithelial cells and transcellular transport involving the transcytosis of materials, eventually mediated by membrane receptors