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Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model

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Mechanistic Comparison# Dosing Comparison# Amycretin Dosing# Amycretin dosing is investigational: Subcutaneous: Once-weekly injection, doses up to 60 mg studied in phase 1b/2a over 36 weeks Oral: Daily tablet, doses up to 50 mg (or 2 x 50 mg) studied in phase 1 Phase 2 T2D: Both subcutaneous and oral formulations studied over 36 weeks Phase 3 dose selection will be informed by the completed phase 2 data

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After reconstitution, most laboratories aliquot the stock and keep it frozen to minimize freeze-thaw cycles that can degrade peptide integrity

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34, 35 IC/BPS is a heterogeneous clinical syndrome

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doi: 10.1097/XCE.0000000000000222 [DOI] [PMC free article] [PubMed] [Google Scholar] 26.Gong X, Zeng X, Fu P

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doi: 10.3978/j.issn.2218-6751.2015.12.03

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