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require documentation of indication, dosing, and clinical response Biologics (IL-12/23 inhibitor): Ustekinumab (Stelara, J3357) FDA-approved for moderate-to-severe CD

Studies testing doses up to 1 mg daily found no additional benefits above this threshold

summary Theres little evidence to support the notion that vitamin B12 deficiency causes weight gain

10.1161/ATVBAHA.111.241893 38 GrimmD.StreetzK

For patients seeking modest metabolic support rather than dramatic fat reduction, they may serve a complementary role

2 While all forms of B12 are well-tolerated by many, methylcobalamin is the form of B12 that is most known for causing some mild side effects related to methylation