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In addition to this, treatment of A549 and H3122 cells with SAG caused an increase in intracellular Fe 2+ concentration, ROS levels and MDA content as well as a decrease in GSH content, which was thus shown to also trigger ferroptosis in lung cancer [217]

According to the results from in vitro and in vivo studies, tanshinone IIA pretreatment protects the liver from APAP-induced liver injury by activating Nrf2 and increasing the mRNA and protein levels of the Nrf2 target genes glutamate-cysteine ligase catalytic subunit (GCLC), NQO1, and HO-1 (Wang et al., 2016)

10.1186/s12866-015-0372-1 144 YokoiY.NakamuraK.YonedaT.KikuchiM.SugimotoR.ShimizuY.et al (2019)

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