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Time needed for improvement ranges from a few days to several weeks, depending on the individual

Though FAD did not directly relate to histamine on SEM analysis, insufficient FAD for good MTHFR activity may provide one explanation since undermethylating environments with insufficient SAMe available for the histamine-metabolizing enzyme N methyl histamine means that there is a tendency for histamine to be conserved and elevated (60)

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doi: 10.1034/j.1600-0633.2002.290402.x

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