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ATG8-defective mice accumulate SQSTM1, resulting in the hyperactivation of NRF2 and limiting oxidative stress [119], whereas Nrf2 - knockout mice exhibit elevated oxidative stress [120]

Datos breves Cmo funciona

Parvathy SS, Masocha W

The relevance of this enzyme is illustrated by the fact that global SOD2 deficiency leads to neonatal death in mice (Huang et al., 1997)

187 Initial results showed that the combination of teclistamab and daratumumab had preliminary efficacy in pretreated patients with MM, while talquetamab and daratumumab showed deep and durable responses in heavily pretreated patients with RRMM