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Activation of the TLR pathway is essential for the normal function of the immune system, but overactivation of this pathway has occurred in UC patients and UC animal models

Studies that have used intra-putamen infusion of GDNF in an open-label format have observed improvements in motor UPDRS scores, as well as some indications of restoration of the nigrostriatal pathway, both pathologically and through imaging

While its hard to attribute its origin to a single individual or group, it was adopted as a method to bypass the gut and rapidly elevate glutathione levels, particularly for patients with Parkinsons, liver dysfunction or heavy toxic burdens, he said

Another critical challenge is mechanistic overlap
