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doi: 10.3390/biology12050676 64 TaghilooSAjamiAAlizadeh-NavaeiRAsgarian-OmranH

The crosstalk between NRF2 and NF-B signaling pathways has been demonstrated after the administration of isoflavones in a mouse model of chronic sleep deprivation

Indeed, autoreactive cells and low-titer autoantibodies are commonly detected in healthy individuals and more frequently in siblings of autoimmune patients ( Several tolerance mechanisms exist in the periphery, including clonal deletion, anergy, immune deviation, ignorance, and active suppression by regulatory T cells (Tregs) (49)

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doi: 10.1172/JCI149759

Mineral nutrition is central to this resilience, as it links structural integrity, metabolism, and signaling (Razzaque and Wimalawansa 2025)