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2016 PMC4718868 Conrad, E

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The conclusion was that alisporivir at a dose of 1200 mg twice daily for 15 days had a significant viral inhibitory effect against HCV-1, HCV-3 and HCV-4.[91] In another study in treatment-nave patients, alisporivir had potent activity against the four most prevalent genotypes of HCV (HCV-1: -4.61 1.88

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Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor

Potential drug efficacy and/or resistance biomarkers were identified on the basis of established metabolic pathways and statistics