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[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Zarbo A, Belum VR, Sibaud V, Oudard S, Postow MA, Hsieh JJ, Motzer RJ, Busam KJ, Lacouture ME
However, PROTACs are typically large and highly polar, with molecular weights often exceeding 800 Da---far beyond Lipinski's Rule of Five (Ro5) for orally bioavailable small-molecule drugs
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Both, mechanical load shifts and exposure of the NP to immune surveillance initiate biological reactions that are injury type specific
