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The studies included in this review focused on key molecular mechanisms involved in PD, such as -synuclein aggregation, sirtuin dysregulation and impaired insulin signaling

Thus, a depletion of GSH is usually associated with an increase in GSSG concentration, and the ratio between reduced and oxidized forms of GSH serves as an important indicator of the redox environment [119121]

doi: 10.2174/157436209789057467 155 MallickI

Due to the toxicity of the oxygen-based derivatives (ROS), the need for protective antioxidants increased, presumably resulting in the evolution of melatonin and other ROS neutralizing or metabolizing species (64)

Notably, the physiological functions of the IVD display diurnal characteristics, reflecting its adaptation to daily cycles

doi: 10.1016/j.tips.2020.09.001 207 YinYChoiSCXuZPerryDJSeayHCrokerBPet al
