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These carriers can be engineered for surface modification with ligands targeting dopaminergic neurons or inflamed brain regions, enabling precision delivery and minimizing off-target toxicity ( 5.4 Gene therapy: targeting underlying molecular defects Gene therapy in PD aims to: Restore dopamine synthesis: e.g., via delivery of aromatic L-amino acid decarboxylase (AADC)

However, the question of causality versus association still remains, and the direct/indirect mechanisms by which the acrolein adducts may lead to injury remain to be determined

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