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have been identified that can affect the rodent liver spontaneously (Ward, Anver, et al

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

and the compounds safety and regulatory status

doi: 10.2147/DDDT.S493049 163 MehlenbacherMRElsiesyRLakhaRVillonesRLEOrmanMVizcarraCLet al

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In a 2020 review, the researchers corroborated that silymarin's capacity to reduce oxidative stress on the liver could indeed improve biomarkers associated with conditions such as alcoholic fatty liver disease, nonalcoholic fatty liver disease, alcoholic cirrhosis, and drug-induced liver injury.29 Although the studies covered in the review used 420mg silymarin doses, others have found that amounts as low as 200mg could also impart the desired effects on liver health.30 If that weren't all, a 2018 study concluded that silymarin may actually increase glutathione levels in the liver.31 Selenium (55mcg) Selenium is an essential mineral with antioxidant properties, and one that may increase levels of an enzyme called glutathione peroxidase (GPx).32 GPx is important because it uses reduced glutathione to neutralize hydrogen peroxide,33 one of the major ROS