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In particular, artificial sweeteners promote purinergic signaling (100), which is associated with depression (66)

But its not true that there is no evidence
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Notably, a similar expression pattern was also found for insulin receptor ( INSR) (Supplementary Fig

Only active ingredients supported by published clinical trial data demonstrating significant improvement in hyperpigmentation (measured by validated clinical scores, colorimetry, or imaging) compared to vehicle or baseline are included in this review
