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J Hepatol 72(6):12121213

DSIP Key Notes Sleep Enhancement: DSIP primarily promotes slow-wave (delta) sleep, supporting restorative processes, memory consolidation, and hormonal regulation

Cardiac arrest in the setting of suspected opioid overdose While the current trend of priorities in cardiac arrest favour CABC rather than ABC, in the patient suspected of opioid overdose, the priorities should be ABC-N the N standing for Naloxone

10.1038/ncb1857 [DOI] [PMC free article] [PubMed] [Google Scholar] Parihar N., Bhatt L

What are the benefits of administering GHK-Cu through a nasal spray

By the end of this post, medical toxicology fellows will recognize and understand: Similar APAP toxicity chain of events in mouse models and human beings Initial NAPQI-induced toxicity characterized by superoxide release from electron transport chain (ETC) complex III Activated JNK produces superoxide release from ETC complex I An amplified oxidative/nitrosative cycle maintains persistent JNK activation and peroxynitrite formation Peroxynitrites important role in producing hepatocellular necrosis Fomepizole demonstrates 2 mechanisms of action: inhibition of CYP2E1, and inhibition of JNK Fomepizoles inhibition of JNK prevents necrosis in mice and human liver cells long after NAPQI formation and GSH depletion It looks complicated, but it is easy to understand if we start at the beginning and build on each step