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In Wilsons disease, that cycle breaks at the level of excretion

[DOI] [PubMed] [Google Scholar] 38.Ishii T, Itoh K, Takahashi S, et al

Extracellular dipeptidase then degrades the Cys-Gly dipeptide and releases Cys as well as Gly

Supporting this is the observation that overexpression of GS failed to increase GSH level whereas overexpression of GCL increased GSH level (Grant et al., 1997)

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