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Both the Federation Nationale des Centres de Lutte Contre le Cancer (FNCLCC) [44] and Pediatric Oncology Group (POG) [45] assign tumors to either a low-grade (POG 1 or 2, FNCLCC 1) or high-grade (POG 3, FNCLCC 1 or 2), on the basis of tumor differentiation, mitosis, and necrosis