inhibition of schistosoma mansoni thioredoxin-glutathione reductase by auranofin Targeting thioredoxin glutathione as a potential antischistosomal drug target Cheminformatics Models for Inhibitors of
Description
Mller T, Johann L, Jannack B, Brckner M, Lanfranchi DA, Bauer H, Sanchez C, Yardley V, Deregnaucourt C, Schrvel J, Lanzer M, Schirmer RH, Davioud-Charvet E (August 2011)

The ratio is normally expressed as [GSSG]/[GSH], and in an oxidative environment there is a resulting reduction of GSH and an increase in GSSG (Reference Desideri, Ciccarone and Ciriolo27)

However, free radicals such as hydroxyl ( OH ) and exhibit distinct behavior in biological systems

Molecular characterization of homo- and heterodimeric mercury(II)-bis-thiolates of some biologically relevant thiols by electrospray ionization and triple quadrupole tandem mass spectrometry

One of the most important is Lysyl oxidase, an enzyme that is required for the cross-linking of collagen and elastin

It was first identified in 1993 in lymphocytic choriomeningitis virus (LCMV)-Docile infected mice, where high-dose administration of the virus resulted in dysfunction and, ultimately, clonal deletion of virus-specific cytotoxic T cells without achieving viral clearance [21]
