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There is a lack of available functional spinal MOR due to this downregulation/desensitization, which leads to a lower analgesic effect of intrathecal injection of opioids compared with intraperitoneal injection and failure to reduce allodynia following neuropathy [130,131,132]

It is of interest that the strongest deterioration of the esophageal mucosa exposed to acid + pepsin solution was observed following inactivation of sensory nerves with capsaicin

The arginine salt formulation dramatically improved oral bioavailability

Novel pathophysiological concepts of inflammatory bowel disease

Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity

J Clin Pharm Ther 2016;41:214-9