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Several causative factors, including ammonia, inflammation, neuroinflammation, and oxidative stress, contribute to its pathogenesis, ultimately leading to abnormalities in neurotransmission and altered neuronal integrity

Type 1 Diabetes (T1D) Type 1 diabetes results from an autoimmune response in which CD4+ and CD8+ cells induce destruction of the pancreatic insulin-producing -cells, leading to insulin deficiency (89, 90)
However, pharmacological inhibition of glutamine utilization in mice also altered the phenotype and effector function of tumor-infiltrate lymphocytes

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L.TaboneM.et al (1997)

In contrast to its neuroprotective role, CHAC1 promotes organ injury in other contexts primarily through ferroptosis regulation
