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It usually presents with pathological changes of glomerular filtration rate below 15 ml/(min1.73m^2), accompanied by retention of metabolites and toxins, and disturbance of water, electrolyte and acid-base balance as the main clinical features ( The elevated levels of TMAO in the blood of patients with ESRD have profound implications for their health status and comorbidities

doi:10.17179/excli2020-3239 [54] Fusobacterium May Help Colorectal Cancer Grow and Spread

Moreover, 40% of patients showed improvement in their Child-Pugh scores [144]

Proc Biol Sci (2009) 276(1663):173745