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[3] Vitamin B 12 deficiency in the US and the UK is estimated to occur in about 6 percent of those under the age of 60, and 20 percent of those over the age of 60

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The receptor sensitivity rationale for cycling is mechanistic rather than directly evidenced

[PubMed] [Google Scholar] 27.Thomas MR, Sneed SM, Wei C, Nail PA, Wilson M, Sprinkle EE., 3rd The effects of vitamin C, vitamin B6, vitamin B12, folic acid, riboflavin, and thiamin on the breast milk and maternal status of well-nourished women at 6 months postpartum

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This indicates that vitamin B at therapeutic doses is very safe in pregnancy
