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Nasal epithelial cells and macrophages are the main cellular sources of oxidative stress in CRSwNP

EZN-2208 is another agent that targets and inhibits translation of HIF-1 mRNA (156)

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10.1038/ncomms7741 105 PanackalA.WuestS

PAMPs are molecular structures derived from pathogens, such as lipopolysaccharides or endotoxins from bacterial cell walls, which are recognized by intracellular pattern recognition receptors, including Toll-like receptors