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In cases of severe vitamin B12 deficiency doctors may also prescribe B12 injections in the muscle

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The experimental values of the W parameter can be correlated by means of regression analysis by using regular polynomials as a function of 1 as follows: These empiric models can be used to estimate the drug solubility by means of back-calculation, resolving this property from the specific W value obtained in the respective polynomial regression (25, 26)