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Under these conditions, ML297 likely activates all GIRK1-containing tetrameric channel species, including the predominant GIRK1/2 heteromeric channel species found in brain (Rifkin et al., 2017)
Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy
Moreover, this therapy could exacerbate pre-existing hypophysitis or autoimmune diseases and further worsen the condition of affected patients (232)
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