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Clinical trial protocols from the Phase 2 NEJM study used a gradual escalation approach, starting at low doses and increasing every four weeks

Dysregulated macrophage polarization is pivotal in RA pathogenesis

The Keap1 cysteine residue-mutant and electrophile-modified Keap1, both of which have lost the ability to ubiquitinate Nrf2, often retain the capacity to bind with Nrf2
The compound's effects on muscle tissue metabolism and cellular energetics during activity-recovery cycles provide a tool for studying the molecular basis of exercise-induced adaptations in mammalian muscle
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