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Description
Receptoraktivering hjer intracellulrt cAMP och uppregulerar MITF och tyrosinas, vilket driver eumelaninsyntes den signalvg som ligger till grund fr forskning om pigmentering och fotoskydd

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doi: 10.1073/pnas.93.1.131

This is because the cells that produce the pigment (melanocytes) are located in the nail matrix, which as you can see in the following image, is the most proximal area of the nail

Protection of the skin against solar damage, by sunburn and suntan either by natural sunlight, tanning beds, or the use of sunlamps, is necessary, especially if a positive family history is given
The significance of microsurgical varicocelectomy in the treatment of subclinical varicocele
