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2.1 Generation of ROS and reproductive vulnerability Oxidative stress arises in reproductive tissues through a convergence of mitochondrial dysfunction, inflammatory activation, and environmental insults, with profound implications for gamete viability and hormonal regulation ( Notably, the structural composition of reproductive cells renders them uniquely vulnerable to oxidative damage: sperm membranes are rich in polyunsaturated fatty acids (PUFAs), which undergo rapid lipid peroxidation

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This inducible genetic re-expression model supports an adipocyte-autonomous role of Ssu72 in regulating adipose tissue expansion and metabolic outcomes

One of the major antioxidant pathways counteracting ferroptosis is System Xc - -GSH-GPX4

doi: 10.3389/fphys.2024.1465649 175 NishiokuT.DohguS.TakataF.EtoT.IshikawaN.KodamaK