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56,57,58 Collectively, these findings suggest that selective enhancement of cardioprotective chaperone functions, rather than broad inhibition, may offer a more viable and safer strategy for HSP-based interventions in heart disease

Studies with complete reporting and rigorous design were rated as "High," while others with some limitations or missing methodological details were rated as "Medium" or "Low." To evaluate the reliability and scientific rigor of the evidence presented in this review, we conducted a methodological quality assessment of the primary clinical trials included