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In addition, the inhalable delivery format is very diverse and includes directly inhaled enzymes, chemicals and nanobodies, as well as delivery assisted by carriers such as lipid-based nanoparticles or exosomes 123,124,125 (Fig

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The data are consistent with the report that decreased PPP flux and G6PD activity might impair NADPH and THF biosynthesis 31

However, GKT136901 was found to scavenge peroxynitrite, which may complicate the interpretation of results from NOX-inhibitory assays (GKT137831 does not scavenge RS)