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Although THC possesses neuroprotective antioxidant properties through non-CB1R pathways [33], it also upregulates plasma inflammatory cytokines [34], increases vulnerability to ischemic stroke in young people [35], increases mitochondrial dysfunction [36, 37] and alters gene pathways associated with mitochondrial oxidative phosphorylation [38]

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Cruciferous vegetables also contain compounds that increase glutathione production in the body

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In contrast, ALDH2 is a mitochondrial enzyme highly expressed in the liver and gastrointestinal tract, exhibiting high catalytic efficiency for acetaldehyde oxidation (121)