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The triggering of macrophage inflammatory pathways is also a critical event in lesion development

For example, GPX4 inhibition is not required for TP53-mediated ferroptosis, although TP53 inhibits SLC7A11 expression

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In conclusion, this study comprehensively reviews the source, physicochemical properties, hepatoprotective effects, molecular mechanisms, toxicity, pharmacokinetics, and current development status of new formulations of API, while deeply exploring the challenges and opportunities in current research

These alternative routes may help overcome some limitations of oral delivery, such as degradation in the GI tract, and offer new opportunities for probiotic therapies

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