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22 In the liver of WT mice, phosphorylation of JNK which is activated by TNF- was increased by Con A administration, whereas its phosphorylation did not increase in the liver of Gpx1 KO mice injected with Con A (Figure 3b)

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In addition, NRF2 confers direct tissue protection by alleviating inflammation-driven pathological damage, at leaset in part through restraining the production of pro-inflammatory mediators (Keleku-Lukwete et al., 2015)

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A nanoemulsion formulation of dacarbazine reduces tumor size in a xenograft mouse epidermoid carcinoma model compared to dacarbazine suspension