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This is further supported in mouse models of acute and chronic inflammation wherein KEAP1 suppression of NRF2 is critical for expansion of CD8 + T cells, metabolic reprogramming, and generation of stem-like T cells which enhance long term immunity [67]

Cell Biol Toxicol 38 , 847864 (2022)

Early plateau suggests faster-than-expected receptor desensitization

It also promotes an increase in energy levels and metabolism by utilizing stored fats as an energy source

Accordingly, inactivation of the GH/IGF-1 axis in the OB lineage compromised bone matrix deposition and mineralization

Collectively, these findings indicate that, under defined pathological and catalytic conditions, GSH can be repurposed from an antioxidant safeguard into a redox driver that amplifies oxidative stress and promotes cell death in tumor and inflammatory contexts