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* ALS : Amyotrophic Lateral Sclerosis ARE : Antioxidant Response Element BCA : Bicinchoninic Acid CSF : Cerebrospinal Fluid DTT : Dithiothreitol ECL : Enhanced Chemiluminescence reagent EDTA : Ethylenediaminetetraacetic Acid EGTA : Ethylene Glycol-bis (2-aminoethylether) N, N,N, N-tetraacetic Acid fALS : Familial ALS GPx : Glutathione Peroxidase GR : Glutathione Reductase GSH : Reduced Glutathione GSSG : Oxidized Glutathione H2DCFDA : 2,7-Dichlorodihydrofluorescein Diacetate HPLC : High-Performance Liquid Chromatograph HRP : Horseradish Peroxidase MDA : Malondialdehyde mutSOD1 : Mutant SOD1 NAM : Nicotinamide Nrf2 : Nuclear Factor Erythroid-2-related Factor PBMCs : Peripheral Blood Mononuclear Cells PBS : Phosphate-Buffered Saline PCA : Principal Component Analysis PMSF : Phenylmethylsulfonyl Fluoride PVDF : Polyvinylidene Difluoride sALS : Sporadic ALS SDS : Sodium Dodecyl Sulfate SOD1 : Superoxide Dismutase 1 Ta : Annealing Temperature TBA : Thiobarbituric Acid t-BHP : tert-Butyl Hydroperoxide undSOD1 : Undetermined SOD1 Mutations vit E : Vitamin E

This study elucidated the in vitro neuroprotective potential of unripe durian fruit pulp extract (UDE) against H2O2-induced neurotoxicity in SH-SY5Y cells and neuroinflammation in lipopolysaccharide (LPS)-stimulated BV-2 cells

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