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Importantly, commonly used in vitro BBB models, such as transwell systems and endothelial cell lines including RBE4, bEnd.3, and hCMEC/D3 monolayers, have important limitations, as they may overpredict permeability and do not fully recapitulate key in vivo BBB features, including physiological shear stress and multicellular neurovascular architecture (Chaulagain et al., 2023)

Providing support for a causal link between a negative energy state and increased Parasutterella abundance, a rat model of obesity, which showed similar Parasutterella relative abundances in animals maintained on HFD and those maintained on normal chow but exhibited a treatment-induced increase in Parasutterella relative abundance, displayed a negative correlation between Parasutterella and body weight 82

They are not approved for human or animal consumption, medical use, or diagnostic purposes

The efficacy and safety of topical 5% methimazole vs 4% hydroquinone in the treatment of melasma: a randomized controlled trial

The efficacy of topical sucralfate in improving pain and wound healing after haemorrhoidectomy procedure: a systematic review, meta-analysis, and meta-regression of randomised clinical trials

doi: 10.3389/fragi.2026.1790247 Received 17 January 2026 Revised 27 February 2026 Accepted 20 March 2026 Published 07 April 2026 Volume 7 - 2026 Edited by Filipe Cabreiro, University of Cologne, Germany Reviewed by Wanzi Yao, Peking University, China Updates Copyright 2026 Mavrych, Shypilova and Bolgova