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In BRAF V600E-mutant CRC, tumor cells often exhibit an initial response to BRAF inhibitors, but frequently develop resistance through reactivation of the MAPK pathway, commonly via KRAS amplification or MEK mutations [76]

Treatment may last from ten days to up to three weeks

3.4.5 Voltage-independent cation channel activation Emerging evidence implicates transient receptor potential (TRP) channels as convergence points for metal neurotoxicity
