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The first anatomical region subjected to filtered toxicants, the PCT with epithelial cells with resorptive capacity, is the most vulnerable region of the kidney 19
As a consequence, the expression of antioxidant enzymes such as catalase and superoxide dismutase (SOD) is induced to defend cells against intracellular oxidative stress
Secondly, we address the issue of whether blocking RAS membrane association is a viable approach
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generated a chimeric antigen receptor T cell (CAR-T) anti-Jag1 therapy capable of activating cytotoxic T cells in Jag1 expressing cell models (132)
generally resolves
