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Overall, these data indicate that there is no clinically relevant effect of hepatic impairment on cagrilintide pharmacokinetics

Gastrointestinal Histology Intestinal tissue damage was analyzed using a histologic scoring scale adapted from Chui and co-workers [62] on a scale from 0 to 5 (normal to severe) in 3 categories (mucosal injury, inflammation, hyperemia/hemorrhage) for a total score of 0 to 15 as described by Lane and co-workers [63]

moderate impairment, n = 7

reduce dose if persistent

Any disruptionLow stomach acid (hypochlorhydria), parietal cell loss (atrophic gastritis), IF deficiency (pernicious anemia), or ileal disease (Crohns)can compromise absorption, leading to deficiency risk

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