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Accordingly, in a recent genome-wide CRISPR-screening, it was reported that the inactivation of the gene coding for the ABC-transporter ABCC1, which pumps GSH-conjugates out of the cell, favours cell growth in the presence of FA 44

Intracellular detection of ROS was achieved by incubating cells with 10 M CM-DCFDA for 30 min at 37C prior to LPS and GHK-Cu treatment

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Therefore, chronic toxic exposure to transition metals and / or organic pollutants, combined with genetic polymorphisms of detoxification phase I+II enzymes and overexpression of transport proteins or their receptors, may be responsible for this phenomenon [43]

In vitro studies have shown that a concentration of 50 M CoQ10 in culture media elevates the expression of Sirt1, a key regulator of mitochondrial function, in cumulus cells