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Diet, lifestyle and genetics are already known to be triggers for oxidative stress

Iron-saturated holo-transferrin (holo-TF) transports irons into cells and releases irons in the acidic endosome to accomplish intracellular iron delivery ( via hydrophobic and van der Waals interactions ( It has been established that artemisinins anti-cancer mechanism acts mainly through the cleavage of the endoperoxide bridge, which eventually induces cell ferroptosis, apoptosis, autophagy, cell cycle arrest, or anti-angiogenesis (, hydrogen peroxide (H 2 O 2 ), hydroxyl radicals (OH), peroxide , and hydroxyl ion (OH - )

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