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While certain senolytic compounds have shown specificity for senescent cells in preclinical models, achieving this selectivity in humans remains a significant hurdle.120 For example, some senescence-associated proteins (eg, BCL-2, p53, SASP factors) are also expressed in normal, proliferating cells, leading to potential off-target effects.31 Therefore, optimizing senolytic agents to minimize side effects while maintaining efficacy is crucial

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We have previously reported that after 1 month of degradation, the PLGA, PLGA/CNT, and PLGA/CNT-lam scaffolds were degraded partially and lost about 20% of their mass [17]

Complete protocols typically use 10-40mg total (2-8 vials) over 4-6 weeks

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L-Carnitine for Anemia in Hemodialysis patients: A last resort