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Furthermore, multiple evidence suggest that alternation in epigenetics regulations, i.e., histone modification and DNA methylation, contribute significantly to pathological diseases and NDs

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The latter modification is consistent with our recent report that parkin thiols participate in redox chemistry to neutralize highly reactive molecules , e.g., H 2 O 2 and dopamine metabolites [53], as well as with the literature on transient S- glutathionylation of redox-sensitive proteins as a cytoprotective mechanism against rising concentrations of ROS [27]