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Dosing Protocol A per-draw reference for the representative ~125 mg/mL MIC + ~1000 mcg/mL B12 vial, converted to U-100 syringe marks

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In line with our findings, other publications have reported that UCP1 and PGC1 expression is increased in the BAT of ATF4-whole body knockout mice, suggesting that ATF4 can act as a negative regulator of uncoupled respiration (Wang et al, 2010)

PMID: 25817057 Abonia JP, Wen T, Stucke EM, Grotjan T, Griffith MS, Kemme KA, Collins MH, Putnam PE, Franciosi JP, von Tiehl KF, Tinkle BT, Marsolo KA, Martin LJ, Ware SM, Rothenberg ME

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A total of 34 metabolites were dysregulated due to radiation exposure (RAD D1vD5) consisting of 22 metabolites identified by NMR (65%) and 12 metabolites identified by LCMS (35%)