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Preclinical research suggests effects related to angiogenesis (VEGF/nitric oxide pathways), anti-inflammatory signaling, and tendon, ligament, muscle, and nerve healing, including cytoprotective effects in ischemia

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229 According to a study by Mizuno et al., integration of bFGF to chitosan films as a delivery vehicle improved the peptides stability and permitted a prolonged release at the wound site

Therefore, caution is needed when extrapolating the findings of this work to COVID-19 patients previously vaccinated or infected with SARS-CoV-2 variants

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